Calcemin Advance is a combination drug that regulates the metabolic processes of calcium and phosphorus in organism.
This remedy replenishes the deficiency of macro- and microelements, calcium and magnesium in the body, and also provides it with vitamins of group D.
The action of the drug is aimed at improving the condition of joints and bones, as a result of which the likelihood of developing diseases that affect the human musculoskeletal system is significantly reduced.
Calcemin Advance: composition and form of release
The drug is sold in the form of biconvex, oval, film-coated tablets, which are characterized by a pink color, which, on the one hand, have a characteristic risk.
1 tablet contains:
- boron (in the form of sodium borate decahydrate) - 250 mcg .;
- calcium (in the form of calcium citrate tetrahydrate and calcium carbonate) - 500 mg;
- manganese (in the form of manganese sulfate) - 1.8 mg .;
- colcalciferol (group D vitamins, in particular D3) - 200 IU;
- copper (in the form of copper oxide) - 1 mg;
- magnesium (in the form of magnesium oxide) - 40 mg .;
- zinc (in the form of zinc oxide) - 7.5 mg.
The manufacturer sells Calcemin Advance in pharmacy chains in the form of high-density polyethylene bottles that contain: 30 pcs, 60 pcs, 120 pcs.
Pharmacological action of the drug
The main purpose of the drug is the regulation of calcium - phosphorus metabolism, which compensates for the deficiency of useful vitamins and minerals in the human body.
Pharmacodynamics
Calcemin Advance is combination drug, an integral part of which are vitamins, macro- and microelements; The positive effect of the drug on the human body is due to the properties that make up the substances.
Calcium plays an important role in the formation of bone tissue, reduces resorption and increases bone density, prevents diseases affecting the musculoskeletal system, has a beneficial effect, which results in strengthening the skeletal system and joints.
Thanks to calcium citrate, absorption of calcium by the body regardless of the state of the gastrointestinal tract, which allows the use of the drug for people with depressed secretory function of the gastrointestinal tract, as well as in parallel with drugs, the purpose of which is to reduce secretion.
Helps to reduce the level of bone resorption markers, which is evidence of a slowdown in the processes that contribute to the destruction of bone matter; the regulation of the level of parathyroid hormone is carried out, which helps to improve the exchange of calcium homeostasis; helps to reduce the concentration of oxalates and calcium in the urine, which significantly reduces the risk of developing urolithiasis; promotes the absorption of iron, which significantly reduces the likelihood of developing iron deficiency anemia.
Calcemin Advance
Colecalciferol (vitamin D3) regulates the metabolism of calcium and phosphorus in the body. Takes an important part in the formation of the bone skeleton, has a beneficial effect on maintaining the structure of bones, enhances the process of assimilation and absorption of calcium in the intestine.
Magnesium is directly involved in the formation of bone and muscle tissue, thanks to its participation, protein synthesis is carried out.
Zinc and magnesium perform the function synthesis of organic bone matrix but.
Due to the action of zinc, the synthesis of sex hormones is carried out, which also prevents the destruction of bone matter. It has a beneficial effect on bone density.
Manganese is involved in the formation of proteoglycans, which improve the condition of bone tissue and form a protein matrix.
Copper is an integral link in the synthesis of collagen and elastin, which is part of the connective and bone matter, which contributes to the formation of new bone mass.
Boron reduces excess parathyroid hormone activity, improving calcium absorption. In parallel, it reduces the risk of developing a deficiency of cholecalciferol.
Indications for Calcemin Advance
Calcemin Advance: contraindications
The drug should be taken with extreme caution during pregnancy and breastfeeding, as well as in the case of diagnosing renal failure.
Use during pregnancy and during breastfeeding (according to instructions)
During childbearing and breastfeeding, the use of Calcemin Advance must be agreed with your doctor without fail. The daily norm of women in position should not exceed 1500 mg of calcium and 600 IU of vitamin D3, since hypercalcemia can cause mental and physical defects in the development of the fetus.
Calcemin Advance: side effects
- With allergic reactions: urticaria, itching, redness of the skin;
- If the digestive system malfunctions: vomiting, nausea, constipation, flatulence or diarrhea;
- With failures of metabolic processes: hypercalciuria and hypercalcemia.
Calcemin Advance: price
The cost of the drug varies, based on the number of tablets in the package. Price and reviews are the most important when buying medication. The average cost of a pack of 30 tablets is from 235 to 400 rubles, with 60 tablets from 530 to 580 rubles. The cost of the drug, with a volume of 120 tablets will vary from 590 to 775 rubles.
Calcemin Advance: reviews
Based on the reviews, the drug is often prescribed for its use in order to strengthen the hair and nail plate. People who have used Calcemin Advance for hair loss, judging by the number and content of reviews, satisfied with the result. For the vast majority of people, the drug helped to get rid of this problem.
Galina Petrovna, 43 years old
For the first time in my life I decided to leave a review, perhaps for someone it will be useful. I have a child, he is 15 years old and he actively began to grow, as a result of which his back began to hurt badly. The doctor said that the skeleton does not keep up with the course of growth, which means that it needs an additional source of vitamins and minerals, attributed to Calcemin Advance. Fortunately, we did not find any side effects, but positive trends were noticed after a few days.
Viktor Stepanovich, Sochi
Hello! The drug Calcemin Advance, as you probably already know, based on reviews, is prescribed to replenish the body useful substances. But I am not satisfied with the presence of additional components in it that can harm me and my child. Vitamins are recommended for the skeletal system during menopause, when the body is deficient in calcium, acquired it during this period and was satisfied. The drug coped with all its tasks.
Lidia Alexandrovna, Moscow
Calcemin advance is a combination drug that regulates phosphorus-calcium metabolism. Compensates for the deficiency of calcium, vitamin D3 and other trace elements - helps strengthen bones and joints, prevents diseases of the musculoskeletal system.
Calcium carbonate is the substance with the highest level of elemental calcium needed by the human body to build bone tissue.
Vitamin D3, which is part of the complex, improves the process of calcium absorption by the body, and also takes an active part in the formation of bone tissue and regeneration processes.
Zinc normalizes the production of enzymes that are necessary for the synthesis of nucleic acids and proteins. Under the influence of the microelement, the processes of tissue regeneration and the growth of new cells are stimulated.
Manganese, which is part of Calcemin Advance, stimulates the production of components that make up bone and cartilage tissues. Copper takes an active part in the formation of collagen and elastin.
Boron regulates the synthesis of parathyroid hormone - parathormone, which is necessary for calcium, magnesium and phosphorus metabolism.
Composition of Calcemin advance (1 tablet):
- calcium (in the form of calcium citrate tetrahydrate and calcium carbonate) - 500 mg;
- magnesium (in the form of magnesium oxide) - 40 mg;
- colecalciferol (vitamin D3) - 200 IU (international units);
- copper (in the form of copper oxide) - 1 mg;
- zinc (in the form of zinc oxide) - 7.5 mg;
- boron (in the form of sodium borate decahydrate) - 0.25 mg;
- manganese (as manganese sulfate) - 1.8 mg.
Clinical and pharmacological group - a drug that affects the phosphorus-calcium metabolism.
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Price in pharmacies
Information about the price of Calcemin advance in pharmacies in Russia is taken from the data of online pharmacies and may differ slightly from the price in your region.
You can buy the drug in pharmacies in Moscow at a price: Calcemin Advance tablets 60 pieces - from 643 to 681 rubles, the cost of a package of 30 tablets - from 449 to 510 rubles.
Terms of dispensing from pharmacies - without a prescription.
Store in a place protected from moisture at temperatures up to 25 °C. Keep away from children. Shelf life - 3 years.
The list of analogues is presented below.
What helps Calcemin advance?
The drug Calcemin advance is prescribed in the presence of diseases musculoskeletal system, diseases of the teeth, as well as in diseases accompanied by loss of bone mass and impaired calcium metabolism.
Prevention and complex treatment of osteoporosis of various origins:
- in women during menopause (natural and surgical);
- in persons taking long-term corticosteroids and immunosuppressants.
Therapy of diseases of the musculoskeletal system:
- to improve the consolidation of traumatic fractures.
To compensate for the deficiency of calcium and trace elements in adolescents. Additionally, it is used to replenish the reserves of trace elements in the body during their increased need (pregnancy, lactation, fractures, intensive growth of the musculoskeletal system).
Instructions for use Calcemin advance, doses and rules
The tablet is taken orally, preferably with meals.
Standard dosages of Calcemin advance, according to the instructions for use, depending on the conditions / diseases:
- (as part of complex treatment): 2 times a day, 1 tablet, the average duration of use is 3 months;
- osteoporosis (prevention): 1 tablet once a day, the average duration of use is 2 months;
- improving the consolidation of traumatic fractures, replenishing the deficiency of trace elements and calcium in adolescents over 12 years old: 1 tablet 1 time per day, the average duration of use is 1–1.5 months.
The therapeutic effect of the treatment develops gradually, so you need to take the pills for at least 30 days. If necessary, the course of therapy is extended to 2 or more months.
Important information
With prolonged use of Calcemin, it is necessary to periodically monitor the level of calcium in the blood and urine.
The drug should not be administered simultaneously with calcium antagonists.
Patients with impaired renal function should always consult a doctor and pass the necessary tests before using the drug.
Use during pregnancy and lactation
During pregnancy and lactation, you should consult your doctor before taking Calcemin Advance.
It must be taken into account that the daily dose for pregnant women should not exceed 1500 mg of calcium and 600 IU of vitamin D3, since an overdose during pregnancy can cause defects in the physical and mental development of the child.
Colecalciferol and its metabolites are excreted from breast milk, which should be taken into account when additionally prescribing calcium and vitamin D3 to the child.
Application features
Before using the drug, read the sections of the instructions for use on contraindications, possible side effects and other important information.
Side effects of Calcemin advance
Instructions for use warns of the possibility of developing side effects of the drug Calcemin advance:
- From the digestive system: nausea, vomiting, flatulence.
- From the side of metabolism: hypercalcemia and hypercalciuria.
- Other: allergic reactions.
Contraindications
Calcemin Advance is contraindicated in the following diseases or conditions:
- urolithiasis disease;
- hypercalcemia;
- hypercalciuria;
- children's age up to 12 years;
- severe renal failure;
- vitamin D hypervitaminosis;
- allergies to soy and peanut butter;
- hypersensitivity to the components of the drug.
Assign with caution: renal failure, pregnancy and breastfeeding.
Overdose
Overdose symptoms are headache, muscle weakness, abdominal pain, diarrhea, vomiting, nausea.
With prolonged use of the drug in doses exceeding the recommended ones (more than 4000 IU / day of vitamin D and 2500 mg of calcium per day), serious toxic effects may occur, the development of renal failure, Burnett's syndrome and the development of calcification leading to nephrolithiasis.
When the first signs of an overdose appear, a reduction in the dose of the drug or its temporary cancellation is required. In case of accidental overdose, induce vomiting, rinse the stomach. If necessary, symptomatic therapy is carried out.
If hypercalciuria exceeds 7.5 mmol per day (300 mg per day), the dose of Calcemin Advance should be reduced or treatment discontinued. Recommended rehydration, the use of "loop" diuretics (for example, furosemide), glucocorticosteroids, bisphosphonates, calcitonin, in severe cases, hemodialysis is prescribed.
List of analogues Calcemin advance
If necessary, replace the drug, there are two options - choosing another drug with the same active ingredient or a drug with a similar effect, but with a different active substance. Drugs with a similar effect are united by the coincidence of the ATX code.
Analogues Calcemin advance, list of drugs:
- Calcium Sandoz;
- Kaltsinova;
- Complivit;
- Pregnavit;
- Duovit;
- Pikovit;
- Vitrum;
- Calcium D3-nycomed;
- Multitabs.
When choosing a replacement, it is important to understand that the price, instructions for use and reviews of Calcemin Advance do not apply to analogues. Before replacing, you must obtain the approval of the attending physician and do not replace the drug yourself.
Multiple reviews speak of the widespread use of Calcemin Advance "for beauty". It is believed that the drug is well strengthened nails, teeth, hair. Doctors have great experience use of the drug in osteoporosis and fractures.
Special Information for Healthcare Professionals
Interactions
With the simultaneous use of the drug Calcemin Advance with vitamin A, the toxicity of vitamin D3 decreases.
Phenytoin, barbiturates, corticosteroids reduce the effectiveness of vitamin D3.
Laxatives reduce the absorption of vitamin D3.
GCS, hormonal contraceptives for systemic use, levothyroxine impair the absorption of calcium ions.
With the simultaneous use of tetracyclines, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is impaired) - at least 2 hours.
With the combined use of the drug Calcemin Advance with cardiac glycosides, their toxicity increases (ECG and clinical condition monitoring is necessary), with thiazide diuretics, the risk of developing hypercalcemia increases, with furosemide and other loop diuretics, calcium excretion by the kidneys increases.
Calcemin Advance is a complex drug that helps to adjust the level of phosphorus-calcium metabolism in blood plasma. The medicine is prescribed for adults and children for the complex treatment and prevention of diseases of the musculoskeletal system. Instructions for use Calcemin Advance will allow you to get acquainted in detail with the pharmacological action of the drug.
Calcemin Advance is a combined preparation that contains micro and macro elements, vitamins; pharmacological action is due to the properties of the components that make up its composition:
- Calcium increases the density and resection of bone tissue, participates in its formation, reduces resorption, strengthens joints and bone tissue. Calcium citrate normalizes the absorption of calcium, regardless of the state of the gastrointestinal tract, which allows the drug to be taken by patients with reduced secretory function of the gastrointestinal tract; reduces the level of bone tissue markers, which indicates a slowdown in the processes of its destruction; regulates the content of calcium, respectively, prevents the formation of kidney stones; promotes the absorption of iron, thereby significantly reducing the risk of developing IDA, regulates the content of parathyroid hormone in the blood, which improves the regulation of calcium homeostasis.
- Colecalciferol (vitamin D 3) regulates and replenishes the exchange of calcium and phosphorus, effectively affects the strengthening of bone structure, affects the reabsorption of phosphorus in the renal canals and the absorption of calcium in the intestines.
- Zinc helps to strengthen bone tissue and has a positive effect on the synthesis of sex hormones.
- Magnesium contributes to the formation of muscle and bone tissue. Magnesium and zinc are necessary for the human body for the process of synthesizing organic bone matrix.
- Copper regulates the process of collagen synthesis, having a positive effect on the formation of bone mass.
- Manganese forms the matrix of bone tissue, participates in the formation of proteoglycans, thereby improving the strength of bone tissue.
- Boron improves calcium absorption, reduces the activity of parathyroid hormone, reduces the risk of developing cholecalciferol deficiency, and prevents the development of osteoporosis.
Release form
Dosage form: tablets.
Tablet color: pink.
Shape: biconvex, oval, risk on one side.
Packing type: polyethylene bottle, each packed in a carton box.
The drug is available in 3 dosages: 30, 60, 120 pcs. in every vial.
The composition of the drug
Active substances in one tablet:
- calcium (calcium carbonate, calcium tetrahydrate);
- cholecalciferol (vitamin D 3);
- magnesium (magnesium oxide);
- zinc (zinc oxide);
- copper (copper oxide);
- manganese (manganese sulfate);
- boron (sodium borate decahydrate).
Excipients:
- core: maltodextrin, sodium lauryl sulfate, soy polysaccharide, stearic acid, croscarmellose sodium, microcrystalline cellulose;
- shell: mineral oil, hypromellose, titanium dioxide, triacetin, magnesium silicate, aluminum varnish (Red No. 40) - 0.315 mg; aluminum varnish (Yellow No. 6) - 0.078 mg, aluminum varnish (Blue No. 1) - 0.05 mg.
Instructions for use
Calcemin Advance has several indications for use. His doctors prescribe for the complex treatment of diseases of the musculoskeletal system and for preventive purposes.
The medicine does not relieve the inflammatory process, pain, does not have an antimicrobial effect, does not help with temperature, it has a different mechanism of action - it provides the body with the necessary trace elements and vitamins.
- therapy and prevention of osteoporosis;
- treatment of many diseases of the musculoskeletal system;
- improved consolidation of fractures and injuries;
- long-term use of immunosuppressants;
- treatment of bone resorption;
- period of menopause;
- lack of calcium;
- preventive measures in dentistry;
- replenishment of trace elements and minerals in a period of increased need (development of the musculoskeletal system, fractures, pregnancy, lactation).
Before you start taking the drug, you need to consult a specialist.
Calcemin Advance for children
Indications for the use of medicine for children:
- deficiency of vitamins and microelements;
- diseases of the musculoskeletal system;
- injuries, fractures, etc.
The dosage of the drug is determined by the specialist after a comprehensive examination.
Pregnancy and lactation
During pregnancy or lactation, Calcemin Advance can only be taken as directed by a doctor. It is forbidden to exceed the dosage of the drug prescribed for this period, since an excess of calcium in the body of a pregnant woman negatively affects the development of the fetus - it leads to hypercalcemia, aortic stenosis syndrome, and epilepsy. Also, the fetus may experience developmental delay and lack of growth.
When breastfeeding, it should be borne in mind that the components of the drug enter the child's body, so it is recommended to take the drug under the supervision of a specialist.
drug interaction
Calcemin Advance can reduce the effectiveness of certain drugs: antibiotics, antivirals, fluorides, phosphates, diuretics, antacids, while reducing the amount of absorbed calcium. With the simultaneous use of several drugs, including Calcemin Advance, you need to notify the doctor about this.
Also, due to the use of orlistan, ion exchange salts and laxatives, the absorption of vitamin D3 can be significantly reduced. Between their receptions it is recommended to take a break of several hours. Phenytoin, carbamazepine, barbiturates, vitamin A can interfere with the absorption of vitamin D3.
Contraindications
This complex drug has some contraindications. Before buying it, be sure to read the instructions. The medicine Calcemin Advance has absolute and relative contraindications.
Absolute contraindications include:
- vitamin D hypervitaminosis;
- hypercalciuria;
- hypercalcemia;
- renal failure in a severe anamnesis;
- sarcoidosis;
- tuberculosis;
- intolerance to the components of the drug;
- age up to 12 years;
- urolithiasis disease;
- allergy to peanut butter, soy.
Relative contraindications (conditions / diseases, in the presence of which the prescription of the drug requires caution and specialist supervision):
- pregnancy and lactation;
- kidney failure.
Dosage
The dosage of Calcemin Advance depends on the etiology of the disease. A complex remedy is taken during a meal. Before taking the drug, you should read the annotation, which recommends the Calcemin Advance regimen:
- osteoporosis (prevention): 1 tab. - once a day, application - 2 months;
- osteoporosis (as part of complex treatment): 2 times a day - 1 table, duration - 3 months;
- replenishment of calcium deficiency, improvement of consolidation of traumatic fractures: once a day, 1 tab., application - 2 months.
Side effects
Most often, Calcemin Advance has no side effects, but with individual intolerance to the components, sensitivity or prolonged use of the drug, some side effects may develop:
- headaches;
- allergic reactions - redness, rashes, urticaria, dry skin;
- on the part of the digestive tract - increased gas formation, abdominal pain, nausea, lack of appetite, a feeling of heaviness in the stomach;
- changes in blood and urine tests - hypercalciuria and hypercalcemia.
Price
Calcemin Advance tablets are sold in dosages - 30, 60, 120 pcs. packaged. If the treatment is several months, the manufacturer offers significant savings when buying 60 or 120 tablets. packaged. This complex drug can be purchased at the pharmacy network, in the online store and ordered from the catalog.
The cost of Calcemin Advance in network pharmacies (average prices):
Analogues
Calcemin Advance has no structural analogues for the main active substance. However, there are many similar medicines based on vitamins and microelements on the pharmaceutical market.
- Vitrum Osteomag (tablets). Manufacturer: Unipharm Inc (USA). The drug has differences in composition, but is used when the same problems occur as Calcemin Advance: osteoporosis, calcium deficiency, vitamin D3, for therapeutic and prophylactic purposes. Contraindicated at the age of up to 12 years and with increased sensitivity of the body to the components of the drug. Produced in the form of tablets: the price is from 378 rubles.
- Calcium-D3 Nycomed (chewable tablets). Manufacturer: Nycomed Pharma AS (Norway). Contains a voluminous list of contraindications, as well as age restrictions. The drug is based on calcium, produced in the form of chewable tablets: 30 pcs., Price from 221 rubles.
Cheap analogues of Calcemin Advance:
Complivit calcium D3 (chewable tablets). Manufacturer: Pharmstandard-UfaVITA (Russia). The drug is in the same pharmacological group as Calcemin Advance, however, it contains only two active ingredients. Indications for use contain the same items. Sold in the form of chewable tablets: 30 pieces, price from 138 rubles.
Overdose
Overdose medicinal product can lead to hypervitaminosis, hypercalciuria, hypercalcemia.
Symptoms of drug overdose: loss of appetite, headache, dizziness, thirst, polyuria, nausea, vomiting, constipation, fatigue, muscle weakness, bone pain, fainting, coma, mental disorders, urolithiasis, rarely - cardiac arrhythmias.
Long-term use of calcium can provoke soft tissue calcification, inflammation of the kidneys.
Overdose treatment. If signs of an overdose are found, the dose should be reduced immediately or the drug should be discontinued. If an overdose is caused by accidental circumstances, induce vomiting and gastric lavage. IN special occasions carry out symptomatic therapy.
Calcemin advance is a regulator of calcium phosphorus metabolism. The role of calcium in the public mind often comes down to the formation of bone tissue. But this function in the body is far from being exhausted: calcium regulates the permeability of the walls of blood vessels, the conduction of impulses through neurons, participates in contractions of skeletal muscles, and is one of the components of the blood coagulation system. Normal absorption of calcium is possible only in the presence of active alkaline phosphatase, which requires vitamin D to activate. the latter tends to accumulate in the body, which, in turn, is fraught with hypervitaminosis. Hypervitaminosis of vitamin D can cause the development of cardiovascular, nervous and hepatic pathology. In this regard, clinicians were forced to limit the duration of treatment with drugs containing vitamin D in a dose of more than 400 IU, which reduced the risk of developing hypervitaminosis, but at the same time, the effectiveness of pharmacotherapy. The latter had a negative effect on individuals with an increased need for calcium, for example, pregnant women. The way out was found by the pharmaceutical company SAGMEL. The composition of their Calcemin Advance, in addition to calcium and vitamin D, also includes zinc, copper, manganese and boron, which also contribute to the best absorption of calcium, which made it possible to reduce the dose of vitamin D without losing the effectiveness of treatment.
Zinc activates more than 200 enzymes, including alkaline phosphatase. Copper takes part in the formation of structural proteins of collagen and elastin, preventing a decrease in bone mineral density. Manganese ensures the normal course of the formation of mucopolysaccharides necessary for the formation of bones and cartilage. Boron controls the activity of parathyroid hormone involved in calcium phosphorus metabolism, magnesium and vitamin D metabolism. Calcemin advance is indicated in the treatment and prevention of osteoporosis (reduction in bone mass), other diseases of the musculoskeletal system associated with impaired calcium phosphorus metabolism, in adolescence - to eliminate lack of calcium and magnesium. The drug is contraindicated in case of individual intolerance to one or more components, nephrolithiasis, increased plasma calcium concentration, urinary excretion per day more than 250 (in women) and 300 (in men) mg of calcium. In pediatrics, Calcemin Advance is used from the age of 12. The frequency of admission in adults and children - twice a day. Single dose - 1 tablet. It is not recommended to exceed the dose set by the manufacturer, because. excess calcium can cause impaired absorption of iron, zinc and other trace elements. During pregnancy and breastfeeding, the drug should be taken in consultation with the doctor.
Pharmacology
Combined drug. Regulates phosphorus-calcium metabolism. Replenishes deficiency of calcium, vitamin D 3 , magnesium, microelements. Helps strengthen bones and joints, prevents diseases of the musculoskeletal system.
Pharmacokinetics
Data on the pharmacokinetics of the drug Calcemin Advance are not provided.Release form
Film-coated tablets Pink colour, elongated capsule-shaped, with a notch squeezed out on one side.
Excipients: maltodextrin - 62.66 mg, microcrystalline cellulose - 50 mg, croscarmellose sodium - 38 mg, acacia - 37.96 mg, stearic acid - 16.33 mg, soy polysaccharide - 15 mg, titanium dioxide - 8.55 mg, sodium lauryl sulfate - 5 mg.
Shell composition: hypromellose (hydroxypropyl methylcellulose) - 17.47 mg, magnesium silicate - 5 mg, triacetin - 3.85 mg, mineral oil - 1.92 mg, FD&C red No. 40 varnish - 210 mcg, FD&C yellow No. 6 varnish - 53 mcg, FD&C blue No. 1 varnish - 27 mcg.
30 pcs. - polyethylene bottles (1) - cardboard packs.
60 pcs. - polyethylene bottles (1) - cardboard packs.
120 pcs. - polyethylene bottles (1) - cardboard packs.
Dosage
Adults and children (over 12 years old) - 1 tab. 2 times/day The drug is administered orally during meals.
Overdose
Symptoms: constipation, nausea and vomiting, hypercalcemia and hypercalciuria.
Treatment: drug withdrawal, symptomatic therapy.
Interaction
Data on the drug interaction of the drug Calcemin Advance is not provided.
Side effects
From the digestive system: nausea, vomiting, flatulence.
From the side of metabolism: hypercalcemia and hypercalciuria.
Other: allergic reactions.
Indications
Prevention and complex treatment of osteoporosis of various origins:
- in women during menopause (natural and surgical);
- in persons taking long-term corticosteroids and immunosuppressants.
Therapy of diseases of the musculoskeletal system:
- to improve the consolidation of traumatic fractures.
To compensate for the deficiency of calcium and trace elements in adolescents.
INSTRUCTION CALCEMINE ADVANCE
pharmachologic effect Calcemin Advance:
Mineral and vitamin complex. Calcium, which is part of the drug, is a building component for bone tissue, regulates the permeability of the vascular wall, participates in the regulation of conductivity in synapses and neuromuscular junctions, participates in the contractile activity of skeletal and smooth muscles, is a necessary component for the blood coagulation process. Calcium is represented in the preparation by carbonate and citrate salts. Calcium carbonate contains the maximum amount of elemental calcium. Calcium citrate reduces the dependence of the process of calcium bioavailability on the state of the gastrointestinal mucosa, prevents calculus formation in the urinary system even in case of prolonged use, and reduces excessive production of parathyroid hormone.
Vitamin D (cholecalciferol) promotes adequate absorption of calcium, participates in the processes of regeneration and bone tissue building.
Zinc is an integral component of various body enzymes (more than 200 types) that synthesize proteins and nucleic acids. It also provides gene expression, regeneration and cell growth. It has a positive effect on the activity of the enzyme alkaline phosphatase.
Manganese contributes to the synthesis of substances that are components of bone and cartilage tissue(glycosaminoglycans). Potentiates the calcium-saving ability of vitamin D.
Copper is involved in the formation of elastin and collagen. Helps to stop the phenomenon of demineralization of bone structures.
Boron normalizes the activity of the parathyroid hormone - parathormone. The latter is involved in the exchange of calcium, cholecalciferol, phosphorus, magnesium. The effect on the mineral metabolism of parathyroid hormone does not depend on the intake of vitamin D3.
Calcium is absorbed from the gastrointestinal tract, eliminated from the body with urine, sweat and feces. Calcium absorption is possible due to the activity of calbindin, an enzyme of the intestinal mucosa. The biosynthesis of calbindin is directly dependent on calcitriol, a vitamin D metabolite.
Vitamin D is absorbed quickly from the intestines. Penetrates into the bones, liver, adrenal glands, adipose tissue, heart muscle. When vitamin D is excreted in the bile, it is reabsorbed. Partially transformed into inactive metabolites.
Zinc is eliminated by the kidneys (10%) and intestines (90%).
Copper is partially absorbed from the intestine, the rest is eliminated unchanged or in the form of insoluble complexes. 80% of the injected copper is excreted in the bile, 16% in the intestines, 4% in the kidneys, and a very small amount in the sweat glands.
Boron after absorption from the intestine is excreted by the kidneys (90%).
Indications for use
Calcemin Advance :
prevention of osteoporosis and other diseases of the musculoskeletal system,
prevention of diseases of the teeth, periodontium,
Compensation for the deficiency of vitamins and minerals in case of their insufficient amount in the diet,
children - in a period of intensive growth,
pregnant and lactating.
Mode of application
Calcemin Advance :
For children over 12 years old and adults - 1 tablet 2 r / s. Children from 5 to 12 years old - 1 tablet 1 r / s. Tablets are taken before meals or during meals. The duration of therapy is determined individually, there are no time limits. Pregnant and lactating mothers are prescribed 1 tablet 2 r / s. The drug is prescribed not earlier than the 20th week of pregnancy.
Side effects
More often observed in case of an overdose of the drug (hypersensitivity reactions to the components of calcemin, nausea, flatulence, vomiting, hypercalciuria, hypercalcemia).
Contraindications
hypersensitivity reactions (allergic) to the components of the drug,
hypercalciuria,
hypercalcemia,
nephrolithiasis.
Pregnancy
Not contraindicated during pregnancy and lactation.
Interaction with other drugs
Calcemin should not be used together with calcium antagonists.
Overdose
Calcemin Advance :
There are no reports of cases of overdose of Calcemin. If the dose has been exceeded, symptomatic treatment is prescribed (gastric lavage, the appointment of heavy drinking, eating foods that are poor in calcium).
Release form
Tablets containing elemental calcium 250 mg, white, capsule-like, notched on one side. Tablets are packed into a polyethylene bottle. In a bottle of 30; 60; 120 tablets.
Storage conditions
Shelf life - 3 years, subject to a temperature of 25-30 ° C. Keep away from light. Keep out of the reach of children.
CompositionCalcemin Advance :
Active substances: calcium citrate 842 mg, calcium carbonate 202 mg, cholecalciferol 50 IU, copper 0.5 mg, zinc 2 mg, boron 50 mcg, manganese - 5 mg.
Inactive ingredients: microcrystalline cellulose, magnesium stearate, acacia, sodium lauryl sulfate, sodium croscarmellose, starch, cottonseed oil, calcium phosphate, gluten, sodium citrate, stearic acid, hydroxypropyl cellulose, maltodextrin, sugar, hydroxypropyl methylcellulose, titanium dioxide, gelatin, tocopherol, polyethylene glycol.
Additionally
At the age of 5 years, it is possible to use the drug only according to strict indications. The drug for children of this age should be taken only under the supervision of a physician.
main parameters
| Name: | CALCEMIN ADVANCE |
| ATX code: | A12AX - |